Infertility Chronic utilization of opioids, for instance codeine, a element of promethazine HCl and codeine phosphate oral Option, might lead to minimized fertility in ladies and males of reproductive potential.
The causal purpose of opioids while in the medical syndrome of hypogonadism is unknown as the various clinical, Actual physical, Life style, and psychological stressors that will affect gonadal hormone ranges haven't been adequately managed for in experiments done to this point [see Adverse Reactions (6)].
Request your pharmacist to give you a measuring gadget that may help you evaluate the proper volume of Promethazine with Codeine Oral Remedy. Do not use a house teaspoon to evaluate your medication. You could possibly accidently consider far too much.
Bronchial asthma and Other Pulmonary Disorder The use of promethazine HCl and codeine phosphate oral Remedy in clients with acute or extreme bronchial asthma in an unmonitored placing or in the absence of resuscitative products is contraindicated [see Contraindications (4)]. Opioid analgesics and antitussives, together with codeine, one of several Energetic elements in promethazine HCl and codeine phosphate oral Alternative, shouldn't be Utilized in people with acute febrile illness related to effective cough or in clients with Serious respiratory sickness where interference with capability to very clear the tracheobronchial tree of secretions would have a deleterious impact on the affected individual’s respiratory function.
are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and can result in significant Unintended effects in the child together with elevated sleepiness, respiratory complications (respiratory melancholy), and Dying. It's not regarded if promethazine can move into your breast milk.
Hemodialysis is not really routinely made use of to reinforce the elimination of codeine or promethazine from your body.
Promethazine HCl and codeine phosphate oral solution exposes patients and also other end users on the hazards of opioid addiction, abuse, and misuse, which can result in overdose and Loss of get more info life. Reserve promethazine HCl and codeine phosphate oral Remedy for use in adult individuals for whom some great benefits of cough suppression are anticipated to outweigh the threats, and in whom an satisfactory evaluation of the etiology from the cough has long been created.
five.fifteen Greater Risk of Seizures in Sufferers with Seizure Diseases The codeine and promethazine in promethazine HCl and codeine phosphate oral Answer may improve the frequency of seizures in individuals with seizure Ailments, and could improve the possibility of seizures transpiring in other clinical options connected to seizures.
Promethazine HCl and codeine phosphate oral Answer just isn't recommended to be used in Expecting Females [see Use in Specific Populations (eight.1)]. Prolonged utilization of promethazine HCl and codeine phosphate oral Remedy through pregnancy may end up in neonatal opioid withdrawal syndrome, which may be existence-threatening Otherwise recognized and treated, and requires management In line with protocols developed by neonatology industry experts.
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Usage of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with promethazine HCl and codeine phosphate oral Alternative necessitates very careful consideration of the consequences over the dad or mum drug, codeine, as well as Energetic metabolite, morphine.
Neuroleptic malignant syndrome (NMS) which can cause Demise. Convey to your Health care provider at once Should you have any of the subsequent signs of NMS:
Promethazine HCl and codeine phosphate oral Resolution is for oral use only. Abuse of promethazine HCl and codeine phosphate oral solution poses a danger of overdose and death.